SELECTED PUBLICATIONS
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ANTIBODY-MEDIATED FEEDBACK MODULATES INTERCLONAL COMPETITION IN THE GERMINAL CENTER
Barbulescu A, Bilanovic J, Langelaar T, de Carvalho RVH, et al. Antibody-mediated feedback modulates interclonal competition in the germinal center. Immunity. 2026 Mar 10;59(3):734-745.e5. doi: 10.1016/j.immuni.2026.01.008. Epub 2026 Feb 24. PMID: 41742422.
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PAN-SARBECOVIRUS PROPHYLAXIS WITH HUMAN ANTI-ACE2 MONOCLONAL ANTIBODIES
Zhang F, Jenkins J, de Carvalho RVH, Nakandakari-Higa S, Chen T, et al. Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies.Nat Microbiol. 2023 Jun;8(6):1051-1063. doi: 10.1038/s41564-023-01389-9. Epub 2023 May 15. PMID: 37188812; PMCID: PMC10234812.
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CLONAL REPLACEMENT SUSTAINS LONG-LIVED GERMINAL CENTERS PRIMED BY RESPIRATORY VIRUSES
de Carvalho RVH, Ersching J, Barbulescu A, Hobbs A, et al. Clonal replacement sustains long-lived germinal centers primed by respiratory viruses.Cell. 2023 Jan 5;186(1):131-146.e13. doi: 10.1016/j.cell.2022.11.031. Epub 2022 Dec 23. PMID: 36565697; PMCID: PMC9870066.
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ENDOSYMBIOTIC RNA VIRUS INHIBITS LEISHMANIA-INDUCED CASPASE-11 ACTIVATION
de Carvalho RVH, Lima-Júnior DS, de Oliveira CV, Zamboni DS. Endosymbiotic RNA virus inhibits Leishmania-induced caspase-11 activation. iScience. 2020 Dec 29;24(1):102004. doi: 10.1016/j.isci.2020.102004. PMID: 33490912; PMCID: PMC7811143.
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INFLAMMASOME ACTIVATION IN RESPONSE TO INTRACELLULAR PROTOZOAN PARASITES
de Carvalho RVH, Zamboni DS. Inflammasome Activation in Response to Intracellular Protozoan Parasites. Trends Parasitol. 2020 May;36(5):459-472. doi: 10.1016/j.pt.2020.02.006. Epub 2020 Mar 23. PMID: 32298633.
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LEISHMANIA RNA VIRUS EXACERBATES LEISHMANIASIS BY SUBVERTING INNATE IMMUNITY VIA TLR3-MEDIATED NLRP3 INFLAMMASOME INHIBITION
de Carvalho RVH, Lima-Junior DS, da Silva MVG, Dilucca M, et al. Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition. Nat Commun. 2019 Nov 21;10(1):5273. doi: 10.1038/s41467-019-13356-2. Erratum in: Nat Commun. 2020 Jan 7;11(1):203. doi: 10.1038/s41467-019-13900-0. PMID: 31754185; PMCID: PMC6872735.
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THE NLRP3 INFLAMMASOME IS INVOLVED WITH THE PATHOGENESIS OF MAYARO VIRUS
de Castro-Jorge LA, de Carvalho RVH, Klein TM, Hiroki CH, et al. The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus. PLoS Pathog. 2019 Sep 3;15(9):e1007934. doi: 10.1371/journal.ppat.1007934. PMID: 31479495; PMCID: PMC6743794.
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MACROPHAGE PRIMING IS DISPENSABLE FOR NLRP3 INFLAMMASOME ACTIVATION AND RESTRICTION OF LEISHMANIA AMAZONENSIS REPLICATION
de Carvalho RVH, Silva ALN, Santos LL, Andrade WA, de Sá KSG, Zamboni DS. Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication. J Leukoc Biol. 2019 Sep;106(3):631-640. doi: 10.1002/JLB.MA1118-471R. Epub 2019 May 7. PMID: 31063608.
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LEISHMANIA LIPOPHOSPHOGLYCAN TRIGGERS CASPASE-11 AND THE NON-CANONICAL ACTIVATION OF THE NLRP3 INFLAMMASOME
de Carvalho RVH, Andrade WA, Lima-Junior DS, Dilucca M, et al. Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome. Cell Rep. 2019 Jan 8;26(2):429-437.e5. doi: 10.1016/j.celrep.2018.12.047. PMID: 30625325; PMCID: PMC8022207.